Epidemiology of Retinoblastoma
نویسندگان
چکیده
It is widely acknowledged that cancers are disorders of cell growth and behavior and that its cause has to be defined at cellular levels. However, studies have shown that the cause of cancer can be deduced from a study of its epidemiology. Sir Percival Pott is credited with linking chemicals to causing cancer when he observed astutely that Chimney sweeps, because of their chronic exposure to sooth, were prone to scrotal cancers. Subsequently, the Danish Chimney sweeps guild ruled that its members must have their bath daily and this prevented the problem.1 Prior to this, John Hill had linked nasal polyps to “immoderate use of snuff”. Epidemiology has also contributed in linking cervical cancer to human papilloma viruses and radiation to different cancers1. It is also important for the purposes of health planning and allocation of resources to know the distribution of any particular disease.
منابع مشابه
Molecular Investigation of the Human Adenovirus in Retinoblastoma Patients
Background and Aims: Retinoblastoma tumors are the most common intraocular malignancy in childhood, leading to death after two years. The Human Adenovirus (HAdV) infection could be critical in the retinoblastoma pathogenesis due to the virus and retinoblastoma 1 interactions. The objective of the current study was to investigate the possible presence of the HAdV genome in the retinoblastoma pat...
متن کاملThe Eye and Orbit
The aetiology of most ocular tumours is not known. Prolonged exposure to sunlight is important in the development of SCC of the eyelids in white cats and possibly in some dogs, as previously described (Chapter 1). Previous trauma and/or chronic inflammation have been reported to incite invasive ocular sarcomas in cats (Dubielzig et al. 1990). Genetic factors are known to be important in the dev...
متن کاملCytotoxicity effect of gold nanoparticles against a rabbit model of retinoblastoma
Introduction: Retinoblastoma is a malignant tumor in children. The goal of retinoblastoma treatment is to maintain vision and minimize side effects. In this study, the toxicity of the gold nanoparticle safety in vitro was investigated on an eye tumor of retinoblastoma under in vivo conditions. Materials and Methods: For the evaluation of the toxicity of gold nanoparticles using MTT test after 4...
متن کاملRetinoblastoma Registry report--Hospital Kuala Lumpur experience.
Retinoblastoma is a childhood ocular cancer. The aim of this paper is to describe the clinical and epidemiological characteristics of patients with retinoblastoma in a major paediatric ophthalmology center in the country. Retrospective information was collected through the retinoblastoma registry. Late presentation with advanced staging is a major problem.
متن کاملA Review of Outstanding Retinoblastoma Researches on RB1 Genes: Focus on Treatment by Non-ionizing and Ionizing Radiation
Introduction: Retinoblastoma (RB) is a malignant retinal tumor, which affects infants and children. This cancer happens through a mutation in the retinoblastoma tumor suppressor genes (RB1). Inactivation of RB1 has been observed in more than 97% of all retinoblastoma patients with mutations. In recent years, RB treatment has developed significantly. RBchr('39')s treatment methods can be one or ...
متن کاملQuantification of Mean Vessel Density in Retinoblastoma and Its Correlation with Local Tumor Invasion and Patients Survival
Background and Objectives: Retinoblastoma is the most common intraocular pediatric malignancy. Angiogenic factor expression such as VEGF (vascular endothelial growth factor) in retinoblastoma can be confirmatory angiogenic potential of this tumor. This study was performed to determine the role of angiogenesis in local invasion of retinoblastoma and its correlation with patients’ sur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012